IDENTIFICATION OF HAPTOGLOBIN SWITCH-ON STATUS IN ARCHIVED PLACENTAL SPECIMENS INDICATES ANTENATAL EXPOSURE TO INFLAMMATION AND POTENTIAL PARTICIPATION OF THE FETUS IN TRIGGERING PRETERM BIRTH

OBJECTIVE: Haptoglobin (Hp) has key immunoregulatory roles that vary with phenotype (Hp1-1, Hp2-1, Hp2-2). Cord blood Hp expression is switched-off in the normal fetus. We hypothesized that in the setting of fetal inflammation placenta becomes inundated with Hp of fetal origin that in turn modulates...

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Publicado no:Placenta
Main Authors: McCarthy, Megan E., Buhimschi, Catalin S., Hardy, John T., Dulay, Antonette T., Laky, Christine A., Bahtyiar, Mert-Ozan, Papanna, Ramesh, Zhao, Guomao, Buhimschi, Irina A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804989/
https://ncbi.nlm.nih.gov/pubmed/29405967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.placenta.2017.12.017
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