NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling

The reactive oxygen species–generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline, with skewing toward an M2 phenotype compared with wi...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Mongue-Din, Heloise, Patel, Ashish S., Looi, Yee H., Grieve, David J., Anilkumar, Narayana, Sirker, Alexander, Dong, Xuebin, Brewer, Alison C., Zhang, Min, Smith, Alberto, Shah, Ajay M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803556/
https://ncbi.nlm.nih.gov/pubmed/29445778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.06.006
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