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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell survival and growth. Here we report that this rescue results from use of asparagine in protein synthesis. All mammalian cell lines tested lacked cytosolic asparaginase activity and could not utilize asparagine to produ...
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| Pubblicato in: | Cell Metab |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803449/ https://ncbi.nlm.nih.gov/pubmed/29337136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.12.006 |
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