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Regulation of kinase activity in the C. elegans EGF receptor, LET-23
In the active HER receptor dimers, kinases play distinct roles; one is the catalytically active kinase and the other is its allosteric activator. This specialization enables signaling by the catalytically inactive HER3, which functions exclusively as an allosteric activator upon heterodimerization w...
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| Udgivet i: | Structure |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803352/ https://ncbi.nlm.nih.gov/pubmed/29358026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.12.012 |
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