Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in D...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Solimena, Michele, Schulte, Anke M., Marselli, Lorella, Ehehalt, Florian, Richter, Daniela, Kleeberg, Manuela, Mziaut, Hassan, Knoch, Klaus-Peter, Parnis, Julia, Bugliani, Marco, Siddiq, Afshan, Jörns, Anne, Burdet, Frédéric, Liechti, Robin, Suleiman, Mara, Margerie, Daniel, Syed, Farooq, Distler, Marius, Grützmann, Robert, Petretto, Enrico, Moreno-Moral, Aida, Wegbrod, Carolin, Sönmez, Anke, Pfriem, Katja, Friedrich, Anne, Meinel, Jörn, Wollheim, Claes B., Baretton, Gustavo B., Scharfmann, Raphael, Nogoceke, Everson, Bonifacio, Ezio, Sturm, Dorothée, Meyer-Puttlitz, Birgit, Boggi, Ugo, Saeger, Hans-Detlev, Filipponi, Franco, Lesche, Mathias, Meda, Paolo, Dahl, Andreas, Wigger, Leonore, Xenarios, Ioannis, Falchi, Mario, Thorens, Bernard, Weitz, Jürgen, Bokvist, Krister, Lenzen, Sigurd, Rutter, Guy A., Froguel, Philippe, von Bülow, Manon, Ibberson, Mark, Marchetti, Piero
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803296/
https://ncbi.nlm.nih.gov/pubmed/29185012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4500-3
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