CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver cancer that predominantly affects young adults with no underlying liver disease. A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1)...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Engelholm, Lars H, Riaz, Anjum, Serra, Denise, Dagnæs-Hansen, Frederik, Johansen, Jens V, Santoni-Rugiu, Eric, Hansen, Steen H, Niola, Francesco, Frödin, Morten
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801691/
https://ncbi.nlm.nih.gov/pubmed/28923495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.09.008
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