Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma

The TP53 gene is the most commonly mutated gene in human cancers and mutations in TP53 have been shown to have either gain-of-function or loss-of-function effects. Using the data generated by The Cancer Genome Atlas, we sought to define the spectrum of TP53 mutations in hepatocellular carcinomas (HC...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Kancherla, Venkatesh, Abdullazade, Samir, Matter, Matthias S., Lanzafame, Manuela, Quagliata, Luca, Roma, Guglielmo, Hoshida, Yujin, Terracciano, Luigi M., Ng, Charlotte K. Y., Piscuoglio, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801302/
https://ncbi.nlm.nih.gov/pubmed/29456550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00002
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