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Real Time In-cell NMR: Ribosome Targeted Antibiotics Modulate Quinary Protein Interactions

It is not well understood how ribosome antibiotics affect a wide range of biochemical pathways; changes in RNA-mediated protein quinary interactions and consequent activity inside the crowded cytosol may provide one possible mechanism. We developed real-time (RT) in-cell NMR spectroscopy to monitor...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Breindel, Leonard, DeMott, Christopher, Burz, David S., Shekhtman, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801172/
https://ncbi.nlm.nih.gov/pubmed/29266932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00938
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