PEROXYNITRITE-INDUCED TYROSINE NITRATION CONTRIBUTES TO MATRIX METALLOPROTEASE-3 ACTIVATION: RELEVANCE TO HYPERGLYCEMIC ISCHEMIC BRAIN INJURY AND TISSUE PLASMINOGEN ACTIVATOR

Matrix metalloprotease-3 (MMP3) activation mediates the tissue plasminogen activator (tPA)-induced hemorrhagic transformation (HT) after stroke. Hyperglycemia (HG) further exacerbates this outcome. We have recently shown that HG increases MMP3 activity in the brain after stroke. However, the combine...

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Veröffentlicht in:Neurochem Res
Hauptverfasser: Hafez, Sherif, Abdelsaid, Mohammed, Fagan, Susan C., Ergul, Adviye
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801117/
https://ncbi.nlm.nih.gov/pubmed/28975464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-017-2411-9
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