Selective Loss of Smaller Spines in Schizophrenia

OBJECTIVE: Deceased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have confirmed that synaptic pruning is largely driven by the loss of large/mature synapses. Thus, increas...

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Veröffentlicht in:Am J Psychiatry
Hauptverfasser: MacDonald, Matthew L., Alhassan, Jamil, Newman, Jason T., Richard, Michelle, Gu, Hong, Kelly, Ryan M., Sampson, Alan R., Fish, Kenneth N., Penzes, Peter, Wills, Zachary P., Lewis, David A., Sweet, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800878/
https://ncbi.nlm.nih.gov/pubmed/28359200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2017.16070814
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