Smad4 Loss Correlates with Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation

OBJECTIVES: The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDA). We examined whether Smad4 tumor status was associated with outcomes following adjuvant chemoradiation (CRT) for resected PDA. METHODS: Patients treated with...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pancreas
Egile Nagusiak: Herman, Joseph M., Jabbour, Salma K., Lin, Steven H., Deek, Matthew P., Hsu, Charles, Fishman, Elliot K., Kim, Sinae, Cameron, John L., Chekmareva, Marina, Laheru, Daniel A., Narang, Amol, Pawlik, Timothy, Hruban, Ralph H., Wolfgang, Christopher L., Iacobuzio-Donahue, Christine A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800523/
https://ncbi.nlm.nih.gov/pubmed/29329157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000985
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