Smad4 Loss Correlates with Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation

OBJECTIVES: The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDA). We examined whether Smad4 tumor status was associated with outcomes following adjuvant chemoradiation (CRT) for resected PDA. METHODS: Patients treated with...

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Detalhes bibliográficos
Publicado no:Pancreas
Main Authors: Herman, Joseph M., Jabbour, Salma K., Lin, Steven H., Deek, Matthew P., Hsu, Charles, Fishman, Elliot K., Kim, Sinae, Cameron, John L., Chekmareva, Marina, Laheru, Daniel A., Narang, Amol, Pawlik, Timothy, Hruban, Ralph H., Wolfgang, Christopher L., Iacobuzio-Donahue, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800523/
https://ncbi.nlm.nih.gov/pubmed/29329157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000985
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