Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction

TL1A, a tumor necrosis factor-like cytokine, is a ligand for the death domain receptor DR3. TL1A, upon binding to DR3, can stimulate lymphocytes and trigger secretion of proinflammatory cytokines. Therefore, blockade of TL1A/DR3 interaction may be a potential therapeutic strategy for autoimmune and...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Huang, Richard Y.-C., Krystek, Stanley R., Felix, Nathan, Graziano, Robert F., Srinivasan, Mohan, Pashine, Achal, Chen, Guodong
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800371/
https://ncbi.nlm.nih.gov/pubmed/29135326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1393595
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