Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation

Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported to have a therapeutic effect on RA and obesity. The aim of this investigatio...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Kim, Eun-Kyung, Lee, Seung Hoon, Lee, Seon-Young, Kim, Jae-kyung, Jhun, Joo Yeon, Na, Hyun Sik, Kim, Se-Young, Choi, Jong Young, Yang, Chul Woo, Park, Sung-Hwan, Cho, Mi-La
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799802/
https://ncbi.nlm.nih.gov/pubmed/29371695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.245
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