Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration

Mucin1 (MUC1), a heterodimeric oncoprotein, containing tandem repeat structures with a high proportion of threonine, is aberrantly overexpressed in many human cancers including pancreatic cancer. Since the overall survival rate of pancreatic cancer patients has remained low for several decades, nove...

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Bibliographic Details
Published in:Exp Mol Med
Main Authors: Jeong, Seung Jae, Kim, Jong Hyun, Lim, Beom Jin, Yoon, Ina, Song, Ji-Ae, Moon, Hee-sun, Kim, Doyeun, Lee, Dong Ki, Kim, Sunghoon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799795/
https://ncbi.nlm.nih.gov/pubmed/29328069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.231
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