Loss-of-function uORF mutations in human malignancies

Ribosome profiling revealed widespread translational activity at upstream open reading frames (uORFs) and validated uORF-mediated translational control as a commonly repressive mechanism of gene expression. Translational activation of proto-oncogenes through loss-of-uORF mutations has been demonstra...

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Publicado en:Sci Rep
Autores principales: Schulz, Julia, Mah, Nancy, Neuenschwander, Martin, Kischka, Tabea, Ratei, Richard, Schlag, Peter M., Castaños-Vélez, Esmeralda, Fichtner, Iduna, Tunn, Per-Ulf, Denkert, Carsten, Klaas, Oliver, Berdel, Wolfgang E., von Kries, Jens P., Makalowski, Wojciech, Andrade-Navarro, Miguel A., Leutz, Achim, Wethmar, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799362/
https://ncbi.nlm.nih.gov/pubmed/29402903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19201-8
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