Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data

Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm and its disappearance from the nucleus are pathological features of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) and are directly involved in the pathogenesis of these conditions. TDP-43 is an essent...

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Detalles Bibliográficos
Publicado en:Front Neurosci
Main Authors: Sugai, Akihiro, Kato, Taisuke, Koyama, Akihide, Koike, Yuka, Kasahara, Sou, Konno, Takuya, Ishihara, Tomohiko, Onodera, Osamu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799296/
https://ncbi.nlm.nih.gov/pubmed/29449800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00028
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