Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster

Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expos...

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Pubblicato in:Sci Rep
Autori principali: Olufs, Zachariah P. G., Loewen, Carin A., Ganetzky, Barry, Wassarman, David A., Perouansky, Misha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799260/
https://ncbi.nlm.nih.gov/pubmed/29402974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20720-7
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