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Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster

Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expos...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Olufs, Zachariah P. G., Loewen, Carin A., Ganetzky, Barry, Wassarman, David A., Perouansky, Misha
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799260/
https://ncbi.nlm.nih.gov/pubmed/29402974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20720-7
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