Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements

Methyl CpG Binding Protein 2 (MeCP2) is an important epigenetic factor in the brain. MeCP2 expression is affected by different environmental insults including alcohol exposure. Accumulating evidence supports the role of aberrant MeCP2 expression in ethanol exposure-induced neurological symptoms. How...

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Bibliographic Details
Published in:Exp Neurol
Main Authors: Liyanage, Vichithra Rasangi Batuwita, Zachariah, Robby Mathew, Davie, James Ronald, Rastegar, Mojgan
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798977/
https://ncbi.nlm.nih.gov/pubmed/25620416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.01.006
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