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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells

BACKGROUND: Aberrant MeCP2 expression in brain is associated with neurodevelopmental disorders including autism. In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2/MECP2 promoter hypermethylation. Altered expression of MeCP2 isoforms (MeCP2E...

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Autori principali: Liyanage, Vichithra R B, Zachariah, Robby M, Rastegar, Mojgan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900258/
https://ncbi.nlm.nih.gov/pubmed/24238559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-4-46
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