Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter

In 2012, we reported that 5 out of 11 subjects in a clinical trial (NCT00372320) administering AdhAQP1 to radiation-damaged parotid glands showed increased saliva flow rates and decreased symptoms over the initial 42 days. AdhAQP1 is a first-generation, E1-deleted, replication-defective, serotype 5...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Zheng, C, Baum, BJ, Liu, X, Goldsmith, CM, Perez, P, Jang, S-I, Cotrim, AP, McCullagh, L, Ambudkar, IS, Alevizos, I
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798873/
https://ncbi.nlm.nih.gov/pubmed/26177970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.55
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