Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system

For many biological processes such as ligand binding, enzymatic catalysis, or protein folding, allosteric regulation of protein conformation and dynamics is fundamentally important. One example is the bacterial adhesin FimH, where the C-terminal pilin domain exerts negative allosteric control over b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rabbani, Said, Fiege, Brigitte, Eris, Deniz, Silbermann, Marleen, Jakob, Roman Peter, Navarra, Giulio, Maier, Timm, Ernst, Beat
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798311/
https://ncbi.nlm.nih.gov/pubmed/29180452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802942
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