E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death

E2F1 is the main pro‐apoptotic effector of the pRB‐regulated tumor suppressor pathway by promoting the transcription of various pro‐apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL‐xL...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Vuillier, Céline, Lohard, Steven, Fétiveau, Aurélie, Allègre, Jennifer, Kayaci, Cémile, King, Louise E, Braun, Frédérique, Barillé‐Nion, Sophie, Gautier, Fabien, Dubrez, Laurence, Gilmore, Andrew P, Juin, Philippe P, Maillet, Laurent
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Scientific Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797968/
https://ncbi.nlm.nih.gov/pubmed/29233828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744046
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