E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death

E2F1 is the main pro‐apoptotic effector of the pRB‐regulated tumor suppressor pathway by promoting the transcription of various pro‐apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL‐xL...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Vuillier, Céline, Lohard, Steven, Fétiveau, Aurélie, Allègre, Jennifer, Kayaci, Cémile, King, Louise E, Braun, Frédérique, Barillé‐Nion, Sophie, Gautier, Fabien, Dubrez, Laurence, Gilmore, Andrew P, Juin, Philippe P, Maillet, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797968/
https://ncbi.nlm.nih.gov/pubmed/29233828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744046
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