A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

Post-menopausal osteoporosis (PMOP) is a metabolic bone disorder characterized by low bone mass and micro-architectural deterioration of bone tissue. The over-activated osteoclastogenesis, which plays an important role in osteoporosis, has become an important therapeutic target. M54 was a bioactive...

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Vydáno v:Front Pharmacol
Hlavní autoři: Xin, Zhi, Jin, Cui, Chao, Liu, Zheng, Zhang, Liehu, Cao, Panpan, Pan, Weizong, Weng, Xiao, Zhai, Qingjie, Zhao, Honggang, Hu, Longjuan, Qin, Xiao, Chen, Jiacan, Su
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797611/
https://ncbi.nlm.nih.gov/pubmed/29441015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00022
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