Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

BACKGROUND: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia and jaundice, two common PDAC-associated conditions. METH...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Prokopchuk, Olga, Grünwald, Barbara, Nitsche, Ulrich, Jäger, Carsten, Prokopchuk, Oleksii L., Schubert, Elaine C., Friess, Helmut, Martignoni, Marc E., Krüger, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797345/
https://ncbi.nlm.nih.gov/pubmed/29394913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4055-9
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