The anillin-related Int1 protein and the Sep7 septin collaborate to maintain cellular ploidy in Candida albicans

Variation in cell ploidy is a common feature of Candida albicans clinical isolates that are resistant to the antifungal drug fluconazole. Here, we report that the anillin-related protein Int1 interacts with septins for coupling cytokinesis with nuclear segregation. Loss of Int1 results in a rapid di...

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Udgivet i:Sci Rep
Main Authors: Orellana-Muñoz, Sara, Dueñas-Santero, Encarnación, Arnáiz-Pita, Yolanda, del Rey, Francisco, Correa-Bordes, Jaime, Vázquez de Aldana, Carlos R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797091/
https://ncbi.nlm.nih.gov/pubmed/29396461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20249-9
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