Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation

Local translation of membrane proteins in neuronal subcellular domains like soma, dendrites and axon termini is well-documented. In this study, we isolated the electrical signaling unit of an axon by dissecting giant axons from mature squids (Dosidicus gigas). Axoplasm extracted from these axons was...

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Vydáno v:Sci Rep
Hlavní autoři: Mathur, Chhavi, Johnson, Kory R., Tong, Brian A., Miranda, Pablo, Srikumar, Deepa, Basilio, Daniel, Latorre, Ramon, Bezanilla, Francisco, Holmgren, Miguel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797086/
https://ncbi.nlm.nih.gov/pubmed/29396520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20684-8
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