Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

PURPOSE: To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin. METHODS AND MATERIALS: HeLa and oropharyng...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Carter, Rachel J., Nickson, Catherine M., Thompson, James M., Kacperek, Andrzej, Hill, Mark A., Parsons, Jason L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Inc 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796827/
https://ncbi.nlm.nih.gov/pubmed/29413288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2017.11.012
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