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Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response

Endonuclease VIII-like protein 1 (NEIL1) is a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism for repairing DNA base damage. Here, we have purified the major E3 ubiquitin ligases from human cells responsible for regulation of NEIL1 by ubiquitylat...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Edmonds, Matthew J., Carter, Rachel J., Nickson, Catherine M., Williams, Sarah C., Parsons, Jason L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314803/
https://ncbi.nlm.nih.gov/pubmed/27924031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw959
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