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Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end stage renal disease

Design of Phase III trials in diabetic nephropathy currently requires patients at high risk of progression defined as within three years of a hard end-point (end stage renal disease, 40% loss of estimated glomerular filtration rate, or death). To improve design of these trials, we used natural histo...

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Dettagli Bibliografici
Pubblicato in:Kidney Int
Autori principali: Yamanouchi, Masayuki, Skupien, Jan, Niewczas, Monika A., Smiles, Adam, Doria, Alessandro, Stanton, Robert C., Galecki, Andrzej, Duffin, Kevin L., Pullen, Nick, Breyer, Matthew D., Bonventre, Joseph V., Warram, James H., Krolewski, Andrzej S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796779/
https://ncbi.nlm.nih.gov/pubmed/28396115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.02.010
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