Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

BACKGROUND: Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fission and f...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Jiang, Sirui, Nandy, Priya, Wang, Wenzhang, Ma, Xiaopin, Hsia, Jeffrey, Wang, Chunyu, Wang, Zhenlian, Niu, Mengyue, Siedlak, Sandra L., Torres, Sandy, Fujioka, Hisashi, Xu, Ying, Lee, Hyoung-gon, Perry, George, Liu, Jun, Zhu, Xiongwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796581/
https://ncbi.nlm.nih.gov/pubmed/29391029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0238-8
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