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Possible Existence of α-Sheets in the Amyloid Fibrils Formed by a TTR(105–115) Mutant
Herein, we combine several methods to characterize the fibrils formed by a TTR(105–115) mutant in which Leu111 is replaced by the unnatural amino acid aspartic acid 4-methyl ester. We find that this mutant peptide exhibits significantly different aggregation behavior than the wild-type peptide: (1)...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5796419/ https://ncbi.nlm.nih.gov/pubmed/29241000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09262 |
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