Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

PURPOSE: A large body of evidence supports a central role for complement activation in the pathobiology of age-related macular degeneration (AMD), including plasma complement component 5a (C5a). Interestingly, C5a is a chemotactic agent for monocytes, a cell type also shown to contribute to AMD. How...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Toomey, Christopher B., Landowski, Michael, Klingeborn, Mikael, Kelly, Una, Deans, John, Dong, Holly, Harrabi, Ons, Van Blarcom, Thomas, Yeung, Yik Andy, Grishanin, Ruslan, Lin, John C., Saban, Daniel R., Bowes Rickman, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2018
Assuntos:
Retinal Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795897/
https://ncbi.nlm.nih.gov/pubmed/29392311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-23134
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