Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

BACKGROUND: The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin, and cortactin. Components of this pathway are often over...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Otsuka, Yutaro, Oikawa, Tsukasa, Yoshino, Hinako, Hashimoto, Shigeru, Handa, Haruka, Yamamoto, Hiroki, Hashimoto, Ari, Sabe, Hisataka
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795291/
https://ncbi.nlm.nih.gov/pubmed/29329590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0212-z
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