Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

BACKGROUND: Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic cells, are the primary hosts for...

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Gepubliceerd in:BMC Biol
Hoofdauteurs: Lerner, Thomas R., Queval, Christophe J., Fearns, Antony, Repnik, Urska, Griffiths, Gareth, Gutierrez, Maximiliano G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795283/
https://ncbi.nlm.nih.gov/pubmed/29325545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-017-0471-6
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