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A novel dysfunctional germline P53 mutation identified in a family with Li-Fraumeni syndrome

Li-Fraumeni Syndrome (LFS), which is a rare dominantly inherited cancer predisposition syndrome, is associated with germline P53 mutations. Mutations of the tumor suppressor protein P53 are associated with more than 50% of human cancers; however, almost 30% of P53 mutations occur rarely and this has...

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Pubblicato in:Am J Cancer Res
Autori principali: Ji, Min, Wang, Lin, Shao, Yuguo, Cao, Wei, Xu, Ting, Chen, Shujie, Wang, Zhiwei, He, Qi, Yang, Kuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794730/
https://ncbi.nlm.nih.gov/pubmed/29416929
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