TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells

Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing TRPM4 levels leads to the reduced proliferation of PC3 cells. This effect was...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Sagredo, Alfredo I., Sagredo, Eduardo A., Cappelli, Claudio, Báez, Pablo, Andaur, Rodrigo E., Blanco, Constanza, Tapia, Julio C., Echeverría, César, Cerda, Oscar, Stutzin, Andrés, Simon, Felipe, Marcelain, Katherine, Armisén, Ricardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792731/
https://ncbi.nlm.nih.gov/pubmed/28614631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12100
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