Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

Thiolutin is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Its biological targets are not known. We show that reduced thiolutin is a zinc-chelator that inhibits the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease Rpn11, a de-ubiquinating enzyme of t...

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Bibliografske podrobnosti
izdano v:Nat Chem Biol
Main Authors: Lauinger, Linda, Li, Jing, Shostak, Anton, Cemel, Ibrahim Avi, Ha, Nati, Zhang, Yaru, Merkl, Philipp E, Obermeyer, Simon, Stankovic-Valentin, Nicolas, Schafmeier, Tobias, Wever, Walter J, Bowers, Albert A, Carter, Kyle P, Palmer, Amy E, Tschochner, Herbert, Melchior, Frauke, Deshaies, Raymond J, Brunner, Michael, Diernfellner, Axel
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792653/
https://ncbi.nlm.nih.gov/pubmed/28459440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2370
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