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Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5

Deubiquitinylases (DUBs) are highly specialized enzymes which are responsible for removal of covalently attached ubiquitin(s) from the targeted proteins. DUBs play an important role in maintaining the protein homeodynamics. Recently, DUBs have emerged as novel therapeutic targets in cancer, inflamma...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Kumar, Vikash, Naumann, Michael, Stein, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189316/
https://ncbi.nlm.nih.gov/pubmed/30356695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00480
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