Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (A...

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Publicado no:Sci Rep
Main Authors: Ikenoue, Tsuneo, Terakado, Yumi, Zhu, Chi, Liu, Xun, Ohsugi, Tomoyuki, Matsubara, Daisuke, Fujii, Tomoki, Kakuta, Shigeru, Kubo, Sachiko, Shibata, Takuma, Yamaguchi, Kiyoshi, Iwakura, Yoichiro, Furukawa, Yoichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792591/
https://ncbi.nlm.nih.gov/pubmed/29386660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19769-1
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