Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (A...

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Publicat a:Sci Rep
Autors principals: Ikenoue, Tsuneo, Terakado, Yumi, Zhu, Chi, Liu, Xun, Ohsugi, Tomoyuki, Matsubara, Daisuke, Fujii, Tomoki, Kakuta, Shigeru, Kubo, Sachiko, Shibata, Takuma, Yamaguchi, Kiyoshi, Iwakura, Yoichiro, Furukawa, Yoichi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792591/
https://ncbi.nlm.nih.gov/pubmed/29386660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19769-1
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