Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication

Influenza A virus nucleoprotein (NP) association with viral RNA (vRNA) is essential for packaging, but the pattern of NP binding to vRNA is unclear. Here we applied photoactivatable ribonucleoside enhanced cross-linking and immunoprecipitation (PAR-CLIP) to assess the native-state of NP–vRNA interac...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Williams, Graham D., Townsend, Dana, Wylie, Kristine M., Kim, Preston J., Amarasinghe, Gaya K., Kutluay, Sebla B., Boon, Adrianus C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792457/
https://ncbi.nlm.nih.gov/pubmed/29386621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02886-w
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