MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD(+) consumption

Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A.1.1 contains a macrodomain able to bind NAD(+) derived metabolites. Here, we report that macroH2A.1.1 is rapidly induced during myogenic di...

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Publicado no:Nat Struct Mol Biol
Main Authors: Posavec Marjanović, Melanija, Hurtado-Bagès, Sarah, Lassi, Maximilian, Valero, Vanesa, Malinverni, Roberto, Delage, Hélène, Navarro, Miriam, Corujo, David, Guberovic, Iva, Douet, Julien, Gama-Perez, Pau, Garcia-Roves, Pablo M., Ahel, Ivan, Ladurner, Andreas G., Yanes, Oscar, Bouvet, Philippe, Suelves, Mònica, Teperino, Raffaele, Pospisilik, J. Andrew, Buschbeck, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791885/
https://ncbi.nlm.nih.gov/pubmed/28991266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3481
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