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Is TFIIH the new Achilles heel of cancer cells?
TFIIH is a 10-subunit complex involved in transcription and DNA repair. It contains several enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-dependent kinase in CDK7. Recently the discovery of several XPB and CDK7 inhibitors with specific impact on the transcription...
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| Publicado no: | Transcription |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5791811/ https://ncbi.nlm.nih.gov/pubmed/28792271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2017.1331723 |
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