18F-methylcholine PET/CT, in vivo magnetic resonance spectroscopy imaging and tissue enzyme biomarkers of choline metabolism in primary brain gliomas

BACKGROUND: Pilot C-11/ F-18 choline PET studies show differential uptake between benign and malignant tumours, however the cellular and molecular basis of this uptake and MRS-visible choline containing compounds (Cho) is not well understood. Choline kinase-α phosphorylates choline, an essential ste...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Grech-Sollars, Matthew, Ordidge, Katherine, Vaqas, Babar, Honeyfield, Lesley, Camp, Sophie, Khan, Sameer, Towey, David, Peterson, David, Roncaroli, Federico, O’Neill, Kevin, Barwick, Tara, Waldman, Adam
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791650/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox238.080
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