Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α

The cellular and molecular basis of choline uptake on PET imaging and MRS-visible choline-containing compounds is not well understood. Choline kinase alpha (ChoKα) is an enzyme that phosphorylates choline, an essential step in membrane synthesis. We investigate choline metabolism through 18F-fluorom...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Grech-Sollars, Matthew, Ordidge, Katherine L, Vaqas, Babar, Davies, Claire, Vaja, Vijay, Honeyfield, Lesley, Camp, Sophie, Towey, David, Mayers, Helen, Peterson, David, O’Neill, Kevin, Roncaroli, Federico, Barwick, Tara D, Waldman, Adam D
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966628/
https://ncbi.nlm.nih.gov/pubmed/31817833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121969
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