Mutational landscape of primary and recurrent glioblastoma reveals potentially actionable SNVs including WNT pathway variation

We used Next-Generation sequencing (NGS) panels to examine somatic variation in a cohort of 41 patients, 8 of which had matched primary biopsies and recurrent biopsies from subsequent tumour resection. 38/41 (92%) of the initial tumours harbour at least one variation in a gene which interacts with t...

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Publicado en:Neuro Oncol
Main Authors: Ellis, Hayley, Sahm, Felix, Schrimpf, Daniel, Stupnikov, Alexei, Wadsley, Mark, Wragg, Christopher, McArt, Darragh, Kurian, Kathreena
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791610/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox238.071
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