Role of mGlu(5) Receptors and Inhibitory Neurotransmission in M(1) Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia

Selective potentiation of the mGlu(5) subtype of metabotropic glutamate (mGlu) receptor using positive allosteric modulators (PAMs) has robust cognition-enhancing effects in rodent models that are relevant for schizophrenia. Until recently, these effects were thought to be due to potentiation of mGl...

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Publicat a:ACS Chem Neurosci
Autors principals: Ghoshal, Ayan, Moran, Sean P., Dickerson, Jonathan W., Joffe, Max E., Grueter, Brad A., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791524/
https://ncbi.nlm.nih.gov/pubmed/28679049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00167
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