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Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
BACKGROUND: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechani...
Zapisane w:
Wydane w: | J Neuroinflammation |
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Główni autorzy: | , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
BioMed Central
2018
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5791311/ https://ncbi.nlm.nih.gov/pubmed/29382344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1059-y |
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